[Controlled clinical research on the potassium-retaining action of various diuretic drugs].

The potassium-retaining action was evaluated in its kaliemic reflexes, in two diuretic associations composed respectively of hydrochlorothiazide + spironolactone and hydrochlorothiazide + amiloride. The potassium intraerythrocytic levels were also determined as well as the natriuresis, the natremia and the daily diuresis. Researches carried out on a group of patients affected by congestive heart failure showed that, the diuretic efficacy being equal, the association of hydrochlorothiazide + spironolactone does not significantly interfere, at the various posologic levels, with the potassium balance. On the contrary, in this regard, the associaiton of amiloride + hydrochlorothiazide appeared to be less manageable because therapeutic dosages showed a tendency to hyperdaliemia.