Giordano M P, Allegri M
Arch Sci Med (Torino). 1976 Aug-Sep;133(3):271-6.
The potassium-retaining action was evaluated in its kaliemic reflexes, in two diuretic associations composed respectively of hydrochlorothiazide + spironolactone and hydrochlorothiazide + amiloride. The potassium intraerythrocytic levels were also determined as well as the natriuresis, the natremia and the daily diuresis. Researches carried out on a group of patients affected by congestive heart failure showed that, the diuretic efficacy being equal, the association of hydrochlorothiazide + spironolactone does not significantly interfere, at the various posologic levels, with the potassium balance. On the contrary, in this regard, the associaiton of amiloride + hydrochlorothiazide appeared to be less manageable because therapeutic dosages showed a tendency to hyperdaliemia.
通过钾血症反射，对分别由氢氯噻嗪+螺内酯和氢氯噻嗪+阿米洛利组成的两种利尿剂组合的保钾作用进行了评估。还测定了红细胞内钾水平以及利钠作用、血钠水平和每日尿量。对一组充血性心力衰竭患者进行的研究表明，在利尿效果相同的情况下，氢氯噻嗪+螺内酯组合在不同剂量水平下对钾平衡没有显著干扰。相反，在这方面，阿米洛利+氢氯噻嗪组合似乎较难控制，因为治疗剂量显示出高钠血症的倾向。
