Wernli M, Bögli F, Mühlebach S, Conen D
Departement Innere Medizin, Kantonsspital Aarau.
Schweiz Med Wochenschr. 1994 Nov 5;124(44):1962-5.
Cytotoxic drugs are frequently used in a hospital setting. They are mainly administered intravenously and require reconstitution and preparation of the solutions. This is commonly done by nurses in the nursing station. However, cytotoxic drugs are potentially hazardous to personnel and patients, and appropriate waste disposal is necessary. Centralized preparation of cytotoxic medication reduces these risks and problems. We review our experience with centralized preparation and controlled application of chemotherapy in a major medical center. It improves overall safety in reducing exposure to the drugs, while errors of dosage and handling can be decreased and costs and volume of hazardous waste are lower to a substantial extent. Central preparation of cytotoxic drugs is feasible and allows improved quality control.
细胞毒性药物常在医院环境中使用。它们主要通过静脉注射给药，需要对溶液进行复溶和配制。这通常由护士在护士站完成。然而，细胞毒性药物对工作人员和患者有潜在危害，因此需要进行适当的废物处理。细胞毒性药物的集中配制可降低这些风险和问题。我们回顾了在一家大型医疗中心进行细胞毒性药物集中配制和控制应用的经验。它在减少药物暴露方面提高了整体安全性，同时可减少剂量和操作错误，并且在很大程度上降低了有害废物的成本和数量。细胞毒性药物的集中配制是可行的，并且可以改善质量控制。
