Capizzi R L
US Bioscience, West Conshohocken, PA 19428.
Semin Oncol. 1994 Oct;21(5 Suppl 11):8-15.
The rationale for the clinical trials with amifostine (Ethyol, US Bioscience, Inc, West Conshohocken, PA) is based on an extensive body of preclinical data coming from many laboratories around the world. Initial clinical trials centered on the hematotoxicity produced by cyclophosphamide, carboplatin, and cisplatin; hematotoxicities and mucosal toxicities from radiation therapy; and nephrotoxicity, neurotoxicity, and ototoxicity from cisplatin.
氨磷汀（Ethyol，美国生物科学公司，宾夕法尼亚州西康舍霍肯）临床试验的理论依据基于来自世界各地众多实验室的大量临床前数据。最初的临床试验集中于环磷酰胺、卡铂和顺铂产生的血液毒性；放射治疗引起的血液毒性和黏膜毒性；以及顺铂导致的肾毒性、神经毒性和耳毒性。
