Dong H H, Liu L
Department of Physiology, Shandong Medical University, Jinan.
Sheng Li Xue Bao. 1994 Jun;46(3):299-303.
The effects of electrical and chemical stimulation of ventromedian area of nucleus hypoglossus (VMNH) on the electrical activities of diaphragm and genioglossus were studied in 25 urethane-anesthetized, vagotomized rabbits. The experimental results were as follows: (1) A 6 s train of electrical stimulation caused a complete cessation of diaphragmatic activities and an excitation of genioglossal activities. (2) A 0.1 s train of stimulation of the nucleus during the middle or late inspiratory phase could elicit an inspiratory off-switch effect. (3) Microinjection of L-glutamate into VMNH also produced an inhibition of diaphragmatic activities. The above observations suggest that VMNH activity exerts a regulatory effect on respiratory rhythm, and this effect may be involved in the central mechanism of swallowing reflex.
在25只经氨基甲酸乙酯麻醉、迷走神经切断的家兔身上，研究了舌下神经核腹内侧区（VMNH）的电刺激和化学刺激对膈肌和颏舌肌电活动的影响。实验结果如下：（1）6秒的一串电刺激可使膈肌活动完全停止，并使颏舌肌活动兴奋。（2）在吸气中期或后期对该核进行0.1秒的一串刺激可引发吸气切断效应。（3）向VMNH微量注射L-谷氨酸也会抑制膈肌活动。上述观察结果表明，VMNH的活动对呼吸节律发挥调节作用，且这种作用可能参与吞咽反射的中枢机制。
