Ma X F, Qiu X C, Tang C S
Department of Physiology, Beijing Medical University.
Sheng Li Xue Bao. 1994 Aug;46(4):399-404.
An experimental model of hypertensive rat was made by abdominal aorta stenosis and hypersaline uptake. The blood pressure was significantly decreased by intracerebroventricular injection (i.c.v.) of BQ123 a potent antagonist of ET-1 receptor, in a dose-dependent manner. Negative chronotropic effect on the heart was produced by high dose of BQ123, while the depressor effect was produced by i.c.v. ET-antiserum. These results indicate that endothelin in CNS may play an important role in the pathological physiology of hypertension.
通过腹主动脉缩窄和高盐摄取建立高血压大鼠实验模型。脑室内注射（i.c.v.）内皮素-1（ET-1）受体的强效拮抗剂BQ123可使血压显著降低，且呈剂量依赖性。高剂量的BQ123对心脏产生负性变时作用，而脑室内注射ET抗血清则产生降压作用。这些结果表明，中枢神经系统中的内皮素可能在高血压的病理生理学中起重要作用。
