美国东南部高中生中与低色素血症和小红细胞症相关的因素。

Factors associated with hypochromia and microcytosis among high school students in the southeastern United States.

作者信息

Adekile A D, Yüregir T Z, Walker E L, Gu L H, Baysal E, Huisman T H

机构信息

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.

出版信息

South Med J. 1994 Nov;87(11):1132-7. doi: 10.1097/00007611-199411000-00015.

DOI:10.1097/00007611-199411000-00015

PMID:7973899

Abstract

We studied hematologic findings in 617 apparently healthy Georgia elementary, middle, and high school students, aged 10 to 19 years, and examined the influence of several parameters (race, sex, iron status, and genetic hemoglobin [Hb] abnormalities) on hypochromia and microcytosis, with or without anemia. Fourteen students (2%) (6 male, 8 female; 4 white, 10 black) were found to be anemic (Hb < 11.8 g/dL in boys or < 11.3 g/dL in girls). Hypochromia (mean corpuscular Hb < 25 pg) with or without microcytosis (mean corpuscular volume < 78 fL) was found in 26 students (4%). Iron deficiency was the main associated factor in white students, but in blacks genetic Hb abnormalities, especially alpha-thalassemia trait, were other predisposing factors. The overall prevalence of iron deficiency (serum ferritin < or = 12 ng/mL) was 32.4% in the entire sample population, 30.5%, among blacks, and 33.2% among whites.

摘要

我们研究了617名年龄在10至19岁之间、看似健康的佐治亚州小学、初中和高中学生的血液学检查结果，并探讨了几个参数（种族、性别、铁状态和遗传性血红蛋白[Hb]异常）对伴有或不伴有贫血的低色素血症和小红细胞症的影响。发现14名学生（2%）（6名男性，8名女性；4名白人，10名黑人）贫血（男孩血红蛋白<11.8 g/dL或女孩血红蛋白<11.3 g/dL）。26名学生（4%）存在伴有或不伴有小红细胞症（平均红细胞体积<78 fL）的低色素血症（平均红细胞血红蛋白<25 pg）。缺铁是白人学生的主要相关因素，但在黑人中，遗传性血红蛋白异常，尤其是α地中海贫血特质，是其他诱发因素。在整个样本群体中，缺铁（血清铁蛋白≤12 ng/mL）的总体患病率为32.4%，黑人中为30.5%，白人中为33.2%。