Demirer T, Ravits J, Aboulafia D
Division of Oncology (Fred Hutchinson Cancer Research Center), University of Washington, Seattle, WA.
South Med J. 1994 Nov;87(11):1186-9. doi: 10.1097/00007611-199411000-00030.
A 66-year-old woman presented clinical findings of Eaton-Lambert (myasthenic) syndrome (ELS). Fifteen months later, large-cell pulmonary carcinoma was detected. After systemic chemotherapy and radiotherapy, the tumor regressed and neurologic function improved. Although ELS is usually associated with pulmonary small-cell carcinoma, a minority of tumors are of squamous or glandular differentiation. We believe this is the first case report of ELS associated with large-cell neuroendocrine carcinoma in the English language literature, and it illustrates the importance of an aggressive approach to diagnosis and treatment.
一名66岁女性出现伊顿-兰伯特（肌无力样）综合征（ELS）的临床症状。15个月后，检测出大细胞肺癌。经过全身化疗和放疗后，肿瘤消退，神经功能改善。虽然ELS通常与肺小细胞癌相关，但少数肿瘤为鳞状或腺性分化。我们认为这是英文文献中首例关于ELS与大细胞神经内分泌癌相关的病例报告，它说明了积极的诊断和治疗方法的重要性。
