Lim P K
Malaria and Filariasis Division, Institute for Medical Research, Kuala Lumpur, Malaysia.
Southeast Asian J Trop Med Public Health. 1993;24 Suppl 2:45-50.
Accurate diagnosis of human filarial infections still remains a problem for clinicians and co-ordinators of filariasis control programs. Diagnosis of filariasis is based on parasitological, histopathological, clinical and immunological approaches. No significant advances have been made for the first three approaches although some refinements in their use and interpretation of results have occurred. For the immunological approach, intradermal tests and antibody detection assays using crude parasite extracts generally lack specificity and/or sensitivity to discriminate between past and present filarial infections in humans. Antigen detection assays would therefore provide a more accurate indication of active filarial infections. Several monoclonal antibodies to various stages of lymphatic filarial parasites have been developed and appear potentially useful for filarial antigen detection.
对于丝虫病控制项目的临床医生和协调人员而言，准确诊断人类丝虫感染仍然是一个难题。丝虫病的诊断基于寄生虫学、组织病理学、临床和免疫学方法。尽管前三种方法在使用和结果解读方面有一些改进，但并未取得显著进展。对于免疫学方法，使用粗制寄生虫提取物的皮内试验和抗体检测试验通常缺乏特异性和/或敏感性，无法区分人类过去和现在的丝虫感染。因此，抗原检测试验将能更准确地指示活动性丝虫感染。已经开发出了几种针对淋巴丝虫寄生虫不同阶段的单克隆抗体，它们似乎对丝虫抗原检测具有潜在用途。
