Datry A, Hilmarsdottir I, Mayorga-Sagastume R, Lyagoubi M, Gaxotte P, Biligui S, Chodakewitz J, Neu D, Danis M, Gentilini M
Département de Maladies Infectieuses, Tropicales et Parasitaires et de Santé Publique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):344-5. doi: 10.1016/0035-9203(94)90110-4.
Ivermectin is highly effective against animal intestinal nematodes and is used in the treatment of onchocerciasis in humans. A study was undertaken to compare the efficacy of the drug with that of albendazole in the treatment of uncomplicated strongyloidiasis. Sixty patients with confirmed Strongyloides stercoralis infection were enrolled in an open randomized study and given either albendazole, 400 mg/d for 3 d or ivermectin, 150-200 micrograms/kg in a single dose. Efficacy and tolerance were evaluated on days 7, 30 and 90. Each visit included a parasitological examination of 3 stool specimens, using saline and Kato smears and formalin-ether and Baermann concentrations. Fifty-three patients were eligible for evaluation. Parasitological cure was obtained in 24 of the 29 patients treated with ivermectin (83%) and in 9 of the 24 patients who were given albendazole (38%); ivermectin was significantly more effective than albendazole (P < 0.01). Clinical and biological adverse reactions were negligible in both treatment groups. The 20 patients who failed therapy were given a second treatment course with 150-200 micrograms/kg of ivermectin in a single dose or on 2 consecutive days. Sixteen patients were cured and the other 4 had only incomplete follow-up. Ivermectin therefore constitutes an acceptable therapeutic alternative for uncomplicated strongyloidiasis.
伊维菌素对动物肠道线虫高效，可用于治疗人类盘尾丝虫病。开展了一项研究，比较该药与阿苯达唑治疗单纯性类圆线虫病的疗效。60例确诊为粪类圆线虫感染的患者纳入一项开放随机研究，给予阿苯达唑400mg/d，连用3天，或伊维菌素150 - 200μg/kg单剂量给药。在第7天、30天和90天评估疗效和耐受性。每次访视包括对3份粪便标本进行寄生虫学检查，采用生理盐水涂片、加藤涂片、福尔马林-乙醚法和贝曼氏浓集法。53例患者符合评估条件。接受伊维菌素治疗的29例患者中有24例（83%）获得寄生虫学治愈，接受阿苯达唑治疗的24例患者中有9例（38%）治愈；伊维菌素的疗效显著优于阿苯达唑（P < 0.01）。两个治疗组的临床和生物学不良反应均可忽略不计。治疗失败的20例患者接受了第二个疗程的治疗，单剂量或连续2天给予150 - 200μg/kg伊维菌素。16例患者治愈，另外4例随访不完整。因此，伊维菌素是单纯性类圆线虫病可接受的治疗选择。
