酵母中的细胞极性

Cell polarity in yeast.

作者信息

Chant J

机构信息

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.

出版信息

Trends Genet. 1994 Sep;10(9):328-33. doi: 10.1016/0168-9525(94)90036-1.

DOI:10.1016/0168-9525(94)90036-1

PMID:7974747

Abstract

Cell polarity is fundamental to the development and functioning of all organisms, from bacteria to humans. Examples of processes that involve cell polarity include the growth of axons, the interaction between T cells and their targets, the formation of buds by yeast, and sporulation in Bacillus spp. Recent work on budding yeast has provided valuable insights into the molecular machinery responsible for establishing and orienting cell polarity. Comparisons of the DNA sequences of genes involved in such pathways have raised the possibility that these mechanisms are conserved in all eukaryotic cells.

摘要

细胞极性对于从细菌到人类的所有生物体的发育和功能至关重要。涉及细胞极性的过程包括轴突的生长、T细胞与其靶标的相互作用、酵母芽的形成以及芽孢杆菌属的孢子形成。最近关于出芽酵母的研究为负责建立和定向细胞极性的分子机制提供了有价值的见解。对参与此类途径的基因的DNA序列进行比较，增加了这些机制在所有真核细胞中保守的可能性。