Opelz G
Abteilung Transplantations-Immunologie, Universität Heidelberg.
Urologe A. 1994 Sep;33(5):377-82.
The success rate of kidney transplants is influenced by many factors. Analysis of the largest available collection of transplant data shows a statistical influence of HLA compatibility, immunosuppression with cyclosporin, donor age, preservation solution with preservation times longer than 24 h, and prophylactic treatment with anti-CMV immunoglobulin in transplants from CMV-positive donors to CMV-negative recipients. Type and duration of pretransplant dialysis and recipient age were not shown to have a significant influence. These results demonstrate that the analysis of retrospective data allows a quantitative estimation of the influence of risk factors. This knowledge can be utilized prospectively to improve the transplant success rate.
肾移植的成功率受多种因素影响。对现有最大规模的移植数据集合进行分析表明，HLA相容性、环孢素免疫抑制、供体年龄、保存时间超过24小时的保存液以及在从巨细胞病毒阳性供体到巨细胞病毒阴性受体的移植中使用抗巨细胞病毒免疫球蛋白进行预防性治疗均具有统计学影响。移植前透析的类型和持续时间以及受体年龄未显示出显著影响。这些结果表明，对回顾性数据的分析能够对风险因素的影响进行定量评估。这一知识可被前瞻性地用于提高移植成功率。
