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[含Ha-ras癌基因启动子的5'PstEJ6.6探针在群体遗传学研究中用于DNA指纹分析]

[The use of the 5'PstEJ6.6 probe containing a Ha-ras oncogene promoter in population genetics research by DNA fingerprinting].

作者信息

Novikov L B, Tlevlesov N, Dukhnovskaia L G, Kalinovskiĭ V P, Khanson K P

出版信息

Vopr Onkol. 1993;39(4-6):178-84.

PMID:7975392
Abstract

The Mendelian inheritance of population genetic markers according to their zygosity has been established in a population investigation carried out in Kazakhstan and the northwestern region of Russia, using the 5'PstEJ6.6 DNA probe genetic variability both for persons of different nationality in a population and between two distant populations has been observed. Said procedure has proved more acceptable than the M13 phage DNA test for mass screening examinations because it involves genome analysis on the basis of DNA markers common to each population.

摘要

在哈萨克斯坦和俄罗斯西北部地区进行的一项人群调查中,已确定了群体遗传标记根据其纯合性的孟德尔遗传方式。使用5'PstEJ6.6 DNA探针,观察到了一个群体中不同国籍人群之间以及两个遥远群体之间的遗传变异性。所述方法已被证明比M13噬菌体DNA检测更适合大规模筛查检查,因为它基于每个群体共有的DNA标记进行基因组分析。

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