Jarosz M, Dzieniszewski J, Kłys W, Kunachowicz H
Kliniki Chorób Metaboliczych i Gastroenterologii Instytutu Zywności i Zywienia w Warszawie.
Wiad Lek. 1993 Oct;46(19-20):741-9.
We studied the utilization of amino acids by the pancreas after its hormonal stimulation in diseases in which disturbances occur of amino acid and protein metabolism. After 45 minutes of intravenous infusion of secretin (1 CU/kg) and cerulein (75 ng/kg) we found a significantly lower (p 0.05) decrease of amino acid concentration than in healthy individuals, both in chronic pancreatitis and in undernutrition and post-inflammatory cirrhosis with decompensation of liver function. Greatest disturbances in amino acid utilization by the pancreas were found in the case of valine, leucine and isoleucine. The results of studies show certain limitations in the use of this method for the assessment of the exocrine function of the pancreas.
我们研究了在氨基酸和蛋白质代谢出现紊乱的疾病中，胰腺在激素刺激后对氨基酸的利用情况。在静脉输注促胰液素（1 CU/kg）和雨蛙素（75 ng/kg）45分钟后，我们发现，无论是在慢性胰腺炎、营养不良以及肝功能失代偿的炎症后肝硬化患者中，氨基酸浓度的下降幅度均显著低于健康个体（p<0.05）。胰腺对缬氨酸、亮氨酸和异亮氨酸的氨基酸利用存在最大的紊乱。研究结果表明，该方法在评估胰腺外分泌功能时存在一定局限性。
