Fischbach W, Böhm S
Medizinische Klinik II, Klinikum Aschaffenburg, Akademisches Lehrkrankenhaus, Universität Würzburg.
Z Gastroenterol. 1994 Jun;32(6):354-9.
The gastrointestinal tract represents the most frequent extranodal manifestation of Non-Hodgkin's lymphoma. Primary gastrointestinal lymphoma which are classified according to the concept of MALT (mucosa-associated-lymphoid-tissue) have to be differentiated from lymphoma involving secondarily the digestive tract. Primary gastric lymphoma which appear at an advanced age can be usually diagnosed endoscopic-bioptically. Representing the major prognostic factors options in the therapy of gastric lymphoma are based on the histologic grading and the stage of disease. Surgical resection and radiotherapy allow a good local tumor control while chemotherapy is the treatment of choice in case of disseminated disease or high malignancy. Characterizing the morphology and molecular biology of primary gastric lymphoma of the MALT, evaluating the role of endoscopic ultrasound in the local staging (EI1, EI2 and EII1), and optimating the therapeutic modalities are main topics of an ongoing prospective multicenter trial.
胃肠道是非霍奇金淋巴瘤最常见的结外表现部位。根据黏膜相关淋巴组织（MALT）概念分类的原发性胃肠道淋巴瘤必须与继发累及消化道的淋巴瘤相鉴别。老年患者出现的原发性胃淋巴瘤通常可通过内镜活检诊断。胃淋巴瘤治疗中的主要预后因素选择基于组织学分级和疾病分期。手术切除和放疗可实现良好的局部肿瘤控制，而化疗是播散性疾病或高恶性肿瘤情况下的首选治疗方法。描述MALT原发性胃淋巴瘤的形态学和分子生物学特征、评估内镜超声在局部分期（EI1、EI2和EII1）中的作用以及优化治疗方式是一项正在进行的前瞻性多中心试验的主要课题。
