Ali S T, Shaikh R N, Siddiqi A
Department of Physiology, University of Karachi, Pakistan.
Acta Neurol Belg. 1994;94(3):194-9.
Value of the bulbocavernosus reflex latency versus nerve conduction velocity of the dorsal nerve of penis and penile brachial index was evaluated in HIV-1 infected asymptomatic and symptomatic men with and without an objective evidence of neuropathy. These studies revealed striking results in neuropathic group. Both asymptomatic and symptomatic patients with neuropathy exhibited a significant decrease (P < 0.0005) in the values of the nerve conduction velocity of the dorsal nerve of penis as well as penile brachial index in comparison with the controls of the same age group. However both types of non neuropathic patients showed a non significant difference in the above mentioned parameters with their respective controls. The latency of bulbocavernosus reflex showed no significant difference between the groups and was within the normal limits. A non significant association in the values of the study parameters among asymptomatic and symptomatic patients with and without neuropathy was also observed. These findings suggest an exclusively apparent sexual pathway for the penile dorsal nerve conduction and penile brachial index in both HIV-1 infected asymptomatic and AIDS positive men affected by neuropathic conditions, irrespective of their disease state. We thus conclude that a primary defective neuropathic mechanism may play an etiological role in the pathogenesis of erectile impotence in these patients.
在有无神经病客观证据的HIV-1感染无症状和有症状男性中，评估了球海绵体反射潜伏期与阴茎背神经传导速度及阴茎肱动脉指数的价值。这些研究在神经病变组中得出了惊人的结果。与同年龄组的对照组相比，有神经病变的无症状和有症状患者的阴茎背神经传导速度以及阴茎肱动脉指数值均显著降低（P < 0.0005）。然而，两种类型的无神经病变患者在上述参数与各自对照组之间均无显著差异。球海绵体反射潜伏期在各组之间无显著差异，且在正常范围内。在有无神经病变的无症状和有症状患者之间，研究参数值也无显著关联。这些发现表明，在受神经病变影响的HIV-1感染无症状和艾滋病阳性男性中，无论其疾病状态如何，阴茎背神经传导和阴茎肱动脉指数均存在明显的性途径。因此，我们得出结论，原发性缺陷性神经病变机制可能在这些患者勃起功能障碍的发病机制中起病因学作用。
