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重组乙型肝炎疫苗免疫后急性小脑性共济失调

Acute cerebellar ataxia after immunisation with recombinant hepatitis B vaccine.

作者信息

Deisenhammer F, Pohl P, Bösch S, Schmidauer C

机构信息

Department of Neurology, University of Innsbruck, Austria.

出版信息

Acta Neurol Scand. 1994 Jun;89(6):462-3. doi: 10.1111/j.1600-0404.1994.tb02667.x.

DOI:10.1111/j.1600-0404.1994.tb02667.x
PMID:7976236
Abstract

We report one woman with acute cerebellar ataxia (ACA), a well-defined clinical syndrome, which occurred 10 days after the second vaccination with recombinant hepatitis B vaccine. The patient had no previous symptoms or signs of neurological disease and there was no evidence of neurologic disease in the family history. Within nine months the symptoms remitted completely according to other reports of ACA. As there was a close temporal connection and no noticeable other cause we assume a causal link between the vaccination and the disease. As far as we known this is the first case of ACA after hepatitis B vaccination.

摘要

我们报告了一名患有急性小脑性共济失调(ACA)的女性,这是一种明确的临床综合征,在第二次接种重组乙型肝炎疫苗10天后出现。该患者既往无神经疾病症状或体征,家族史中也无神经疾病证据。根据其他关于ACA的报告,症状在九个月内完全缓解。由于存在密切的时间关联且无明显的其他病因,我们推测疫苗接种与该疾病之间存在因果关系。据我们所知,这是首例接种乙型肝炎疫苗后发生ACA的病例。

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Cerebellar ataxia and neuropathy as presenting features of hepatitis-B related cirrhosis and portal hypertension.小脑共济失调和神经病变作为乙型肝炎相关肝硬化和门静脉高压的首发症状。
BMJ Case Rep. 2017 Oct 19;2017:bcr-2017-221912. doi: 10.1136/bcr-2017-221912.
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Hepatitis B vaccine and neurotoxicity.
乙肝疫苗与神经毒性。
Postgrad Med J. 1997 Jul;73(861):462-3. doi: 10.1136/pgmj.73.861.462.