Horváth G, Nagy K
EGIS Gyógyszergyár Rt., Budapest.
Acta Pharm Hung. 1994 Jul;64(4):135-40.
The purpose of our work was the studying of the in vitro dissolution behavior of suppositories containing piroxicam as active ingredient with the Flow-through method comparing the results with the ones obtained by the conventional stirred vessel-USP Paddle and Basket methods. The results indicate that the Flow-through method seems to be useful for studying the dissolution process of suppositories containing piroxicam giving reproducible dissolution data. The Flow-through cell method gives faster in vitro dissolution rates for piroxicam than those with the USP Paddle method, probably caused by steeper concentration gradient at the vicinity of the suppositories as well as better ability to uniformly wet them. The USP Basket method was found to give substantially slower dissolution rates than the other two methods.
我们工作的目的是采用流通法研究以吡罗昔康为活性成分的栓剂的体外溶出行为，并将结果与通过传统搅拌容器法（美国药典桨法和篮法）获得的结果进行比较。结果表明，流通法似乎有助于研究含吡罗昔康栓剂的溶出过程，能给出可重现的溶出数据。与美国药典桨法相比，流通池法使吡罗昔康的体外溶出速率更快，这可能是由于栓剂附近的浓度梯度更陡以及更能均匀地润湿栓剂所致。发现美国药典篮法的溶出速率比其他两种方法慢得多。
