Ling Q, Guo Z G, Su Z, Guo X
Research Section of Pharmacology, Hu'nan Medical University, Changsha, China.
Zhongguo Yao Li Xue Bao. 1994 May;15(3):206-10.
To test the effect of losartan and captopril on cardiac hypertrophy and myosin isoenzyme, two-kidney, one-clip (2K 1C) renovascular hypertensive rats (RHR) were used. Eight weeks after the onset of hypertension, losartan 5 mg.kg-1.d-1 and captopril 50 mg.kg-1.d-1 were administered p.o. to 2 groups of RHR, respectively for 8 wk. The results showed that captopril significantly decreased the cardiac mass (607 +/- 169 mg vs 1029 +/- 132 mg) and total protein content (120 +/- 38 mg vs 198 +/- 31 mg), concomitant with significant decrease of arterial blood pressure (BP) (15.4 +/- 5.2 kPa vs 28.5 +/- 4.9 kPa). Losartan also induced a significant decrease in cardiac mass (671 +/- 116 mg vs 1029 +/- 132 mg) and protein content (142 +/- 29 mg vs 198 +/- 31 mg), as well as significantly lowered the BP (15.2 +/- 2.1 kPa vs 28.5 +/- 4.9 kPa). It is important to be note that both drugs normalized the shift of myosin isoenzyme in RHR. These results indicated that both drugs, having potent antihypertensive effects, can effectively reverse the cardiac hypertrophy and abnormal distribution of myosin isoenzyme patterns.
为了测试氯沙坦和卡托普利对心肌肥大和肌球蛋白同工酶的影响，采用两肾一夹（2K 1C）肾血管性高血压大鼠（RHR）。高血压发作8周后，分别对两组RHR口服给予氯沙坦5 mg.kg-1.d-1和卡托普利50 mg.kg-1.d-1，持续8周。结果显示，卡托普利显著降低了心脏重量（607±169 mg对1029±132 mg）和总蛋白含量（120±38 mg对198±31 mg），同时动脉血压（BP）显著降低（15.4±5.2 kPa对28.5±4.9 kPa）。氯沙坦也使心脏重量（671±116 mg对1029±132 mg）和蛋白含量（142±29 mg对198±31 mg）显著降低，并且显著降低了血压（15.2±2.1 kPa对28.5±4.9 kPa）。需要注意的是，两种药物都使RHR中肌球蛋白同工酶的转变恢复正常。这些结果表明，两种药物具有强大的降压作用，能够有效逆转心肌肥大和肌球蛋白同工酶模式的异常分布。
