Noll G, Elam M, Kunimoto M, Karlsson T, Wallin B G
Department of Clinical Neurosciences, Sahlgren Hospital, University of Göteborg, Sweden.
Acta Physiol Scand. 1994 Jul;151(3):319-29. doi: 10.1111/j.1748-1716.1994.tb09751.x.
Multi-unit sympathetic skin nerve activity (SSA) in the peroneal nerve was recorded together with electrical skin resistance, skin blood flow and (in some subjects) finger blood pressure during sleep in 22 sleep-deprived healthy subjects. The average strength of sympathetic activity in different sleep stages was measured during 5-min periods as the area-under-curve of the integrated neurogram. Stage 2 sleep was reached by 15 subjects, stages 3-4 by nine and rapid eye movement (REM) sleep by six subjects. Non-REM sleep was always associated with an increased skin resistance, which was larger in glabrous than in hairy skin (293 +/- 48 vs. 175 +/- 4% of awake control level, n = 10, P < 0.05). Skin blood flow also increased during sleep, with a mean maximal increase of 397 +/- 79% of the awake control level (n = 11, P < 0.05). In spite of these changes of effector function no significant difference in mean SSA was found between the awake control period and periods of non-REM sleep, but during REM sleep SSA increased with 34% (P < 0.05) compared with the immediately preceding stage 2 period. In stage 2 sleep, K-complexes were associated with bursts of SSA followed by transient changes of skin resistance, blood flow and arterial blood pressure. When both skin resistance and blood flow were recorded within the innervation area of the impaled fascicle, single bursts or short periods of increased SSA could be succeeded by increased skin blood flow without concomitant skin resistance change. This indicates the existence of specific sympathetic vasodilator fibres in the skin. Therefore the unchanged strength of multiunit SSA during non-REM sleep in the face of increases of skin resistance and blood flow may be a consequence of an increased sympathetic vasodilator nerve activity combined with decreases of vasoconstrictor and sudomotor traffic.
在22名睡眠剥夺的健康受试者睡眠期间，记录了腓总神经的多单位交感皮肤神经活动（SSA），同时记录了皮肤电阻、皮肤血流量以及（部分受试者的）手指血压。在5分钟时间段内，将整合神经图的曲线下面积作为不同睡眠阶段交感神经活动的平均强度进行测量。15名受试者进入了第2阶段睡眠，9名进入了第3 - 4阶段睡眠，6名进入了快速眼动（REM）睡眠。非快速眼动睡眠总是伴随着皮肤电阻增加，无毛皮肤的增加幅度大于有毛皮肤（分别为清醒对照水平的293±48%和175±4%，n = 10，P < 0.05）。睡眠期间皮肤血流量也增加，平均最大增幅为清醒对照水平的397±79%（n = 11，P < 0.05）。尽管效应器功能发生了这些变化，但在清醒对照期和非快速眼动睡眠期之间，平均SSA未发现显著差异，但与紧接的第2阶段相比，快速眼动睡眠期间SSA增加了34%（P < 0.05）。在第2阶段睡眠中，K复合波与SSA爆发相关，随后皮肤电阻、血流量和动脉血压出现短暂变化。当在穿刺束的神经支配区域内同时记录皮肤电阻和血流量时，单个SSA爆发或短暂增加后可能会出现皮肤血流量增加，而皮肤电阻无相应变化。这表明皮肤中存在特定的交感舒血管纤维。因此，在非快速眼动睡眠期间，面对皮肤电阻和血流量增加，多单位SSA强度不变可能是交感舒血管神经活动增加，同时血管收缩和汗腺分泌活动减少的结果。
