使用扩散加权磁共振成像观察自发性高血压大鼠卒中后水肿变化的体内分化情况。

In vivo differentiation of edematous changes after stroke in spontaneously hypertensive rats using diffusion weighted MRI.

作者信息

Takahashi M, Fritz-Zieroth B, Chikugo T, Ogawa H

机构信息

Research Department, Nihon Schering, Japan.

出版信息

Acta Neurochir Suppl (Wien). 1994;60:224-7. doi: 10.1007/978-3-7091-9334-1_60.

DOI:10.1007/978-3-7091-9334-1_60

PMID:7976552

Abstract

Apparent diffusion coefficients (ADCs) of tissue water were determined in chronic brain lesions of a rat stroke model, the stroke-prone spontaneously hypertensive rat, and compared with histology. ADCs increased in the order normal < edema < gliosis < cyst. The differences between individual groups were statistically significant. The increase in ADC is thought to mainly reflect a relative increase in the extracellular space in brain tissue. ADC may be a new parameter for tissue characterization.

摘要

在大鼠中风模型（易中风自发性高血压大鼠）的慢性脑损伤中测定了组织水的表观扩散系数（ADC），并与组织学结果进行了比较。ADC按照正常＜水肿＜胶质增生＜囊肿的顺序升高。各个组之间的差异具有统计学意义。ADC的升高被认为主要反映了脑组织细胞外间隙的相对增加。ADC可能是一种用于组织特征描述的新参数。