通过磁共振成像评估甘露醇对局灶性脑缺血的影响。

Effect of mannitol on focal cerebral ischemia evaluated by magnetic resonance imaging.

作者信息

Kobayashi H, Ide H, Kodera T, Handa Y, Kabuto M, Kubota T, Maeda M

机构信息

Department of Neurosurgery, Fukui Medical School, Japan.

出版信息

Acta Neurochir Suppl (Wien). 1994;60:228-30. doi: 10.1007/978-3-7091-9334-1_61.

DOI:10.1007/978-3-7091-9334-1_61

PMID:7976553

Abstract

We have evaluated the effect of mannitol on focal cerebral ischemia using T2-weighted magnetic resonance (MR) imaging and intravoxel incoherent motion (IVIM) MR imaging. The left middle cerebral artery (MCA) was exposed via the transorbital approach in 20 adult cats and occluded just proximal to the origin of the perforating arteries. Seven cats in treatment group received mannitol (0.5 g/kg i.v.) at 0, 6, 12 and 18 hours after MCA occlusion. The other 13 cats received saline and served as controls. Sequential MR coronal images were obtained at 2, 4, 6, and 24 hours after MCA occlusion using a GE Signa (1.5 tesla) system. IVIM MR imaging demonstrated ischemic cerebral injury as a sharply demarcated area at 2 hours after MCA occlusion in control group, while T2-weighted MR imaging failed to show clear evidence of the injury until 2-6 hours. At 24 hours after MCA occlusion, the infarcted area in the mannitol treatment group was 36.9 +/- 7.7% (S.E.M) of the left hemisphere, as compared to 57.3 +/- 5.3% in control group (p < 0.05). Mannitol has beneficial effect on ischemic injury.

摘要

我们使用T2加权磁共振（MR）成像和体素内不相干运动（IVIM）MR成像评估了甘露醇对局灶性脑缺血的影响。通过经眶入路暴露20只成年猫的左大脑中动脉（MCA），并在穿支动脉起源的近端进行闭塞。治疗组的7只猫在MCA闭塞后0、6、12和18小时接受甘露醇（0.5 g/kg静脉注射）。另外13只猫接受生理盐水并作为对照。使用GE Signa（1.5特斯拉）系统在MCA闭塞后2、4、6和24小时获得连续的MR冠状图像。IVIM MR成像显示，在对照组中，MCA闭塞后2小时缺血性脑损伤为界限清晰的区域，而T2加权MR成像直到2 - 6小时才显示出明显的损伤证据。在MCA闭塞后24小时，甘露醇治疗组的梗死面积为左半球的36.9 +/- 7.7%（标准误），而对照组为57.3 +/- 5.3%（p < 0.05）。甘露醇对缺血性损伤有有益作用。