自发性高血压大鼠慢性局灶性缺血时的血脑屏障、脑血流量及脑水肿

Blood-brain barrier, cerebral blood flow, and brain edema in spontaneously hypertensive rats with chronic focal ischemia.

作者信息

Shima K, Ohashi K, Umezawa H, Chigasaki H, Okuyama S

机构信息

Department of Neurosurgery, National Defense Medical College, Saitama, Japan.

出版信息

Acta Neurochir Suppl (Wien). 1994;60:271-3. doi: 10.1007/978-3-7091-9334-1_72.

DOI:10.1007/978-3-7091-9334-1_72

PMID:7976564

Abstract

This study was conducted to explore the participation of blood-brain barrier (BBB) permeability and cerebral blood flow (CBF) on the development of ischemic brain edema in rats with chronic arterial hypertension. Young spontaneously hypertensive rats were used, and focal ischemia was produced by occluding the distal middle cerebral artery (MCA). On day 7 after MCA occlusion, BBB permeability and CBF were measured by autoradiographic methods using 14C-alpha-amino-isobutyric acid (AIB) and 14C-iodoantipyrine. BBB permeability (transfer constant for AIB) was significantly higher in the ischemic center and periphery. The CBF of the ischemic cortex showed a graded reduction from the ischemic center to the surrounding area. The ischemic brain regions showed significantly decreased specific gravity. We conclude that SHRSP may be more vulnerable to BBB disruption after ischemia.

摘要

本研究旨在探讨血脑屏障（BBB）通透性和脑血流量（CBF）在慢性动脉高血压大鼠缺血性脑水肿发展过程中的作用。选用年轻的自发性高血压大鼠，通过闭塞大脑中动脉（MCA）远端造成局灶性缺血。在MCA闭塞后第7天，采用放射性自显影法，使用14C-α-氨基异丁酸（AIB）和14C-碘安替比林测量BBB通透性和CBF。缺血中心和周边的BBB通透性（AIB转运常数）显著更高。缺血皮层的CBF从缺血中心到周边区域呈分级降低。缺血脑区的比重显著降低。我们得出结论，自发性高血压大鼠卒中后可能更容易发生血脑屏障破坏。