在局灶性脑梗死中，N-甲基-D-天冬氨酸拮抗剂对脑肿胀的影响是否比对缺血性损伤的影响大得多？

Do N-methyl-D-aspartate antagonists have disproportionately greater effects on brain swelling than on ischemic damage in focal cerebral infarction?

作者信息

Park C K, McCulloch J, Jung D S, Kang J K, Choi C R

机构信息

Department of Neurosurgery, Catholic University Medical College, Seoul, Korea.

出版信息

Acta Neurochir Suppl (Wien). 1994;60:279-81. doi: 10.1007/978-3-7091-9334-1_74.

DOI:10.1007/978-3-7091-9334-1_74

PMID:7976566

Abstract

Using a frozen section technique, we have assessed the effects of N-methyl-D-aspartate (NMDA) antagonist upon brain swelling caused by ischemic brain edema in a rat model of focal cerebral infarction. Although pretreatment with the competitive NMDA antagonist, D-CPPene or the noncompetitive NMDA antagonist, CNS 1102 reduced both the volumes of infarction and ischemic edema in the cerebral hemisphere, mean reduction in brain edema was proportionately similar to decrease in infarct volume in the same animals (correlation coefficient, r = 0.82, p < 0.001). There was, therefore, no evidence of disproportionately greater effects with NMDA antagonist upon brain edema.

摘要

采用冷冻切片技术，我们在局灶性脑梗死大鼠模型中评估了N-甲基-D-天冬氨酸（NMDA）拮抗剂对缺血性脑水肿所致脑肿胀的影响。尽管用竞争性NMDA拮抗剂D-CPPene或非竞争性NMDA拮抗剂CNS 1102预处理可减少大脑半球的梗死体积和缺血性水肿，但同一动物脑水肿的平均减少量与梗死体积的减少量成比例相似（相关系数，r = 0.82，p < 0.001）。因此，没有证据表明NMDA拮抗剂对脑水肿有不成比例的更大影响。