Nomura T, Ikezaki K, Matsukado K, Fukui M
Department of Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Acta Neurochir Suppl (Wien). 1994;60:400-2. doi: 10.1007/978-3-7091-9334-1_108.
We studied the effect of intracarotid administration of histamine on the blood-tumor barrier permeability and also on the blood-brain barrier permeability in transplanted rat C6 glioma. There was no definite Evans blue (EB) extravasation either in normal or tumor tissue after intracarotid saline infusion. In contrast, histamine at doses of 1 and 10 micrograms/kg/min produced slight to moderate EB extravasation in the tumor without any significant extravasation in the normal brain tissue. Intravenously administered H1 and H2 receptor antagonists (5 mg/kg each) reduced the histamine (10 micrograms/kg/min) induced extravasation of EB in the tumor tissue. These results indicated that brain tumor vessels responded to histamine in a different fashion from normal brain capillaries. Histamine could thus be utilized for selective drug delivery to brain tumors without affecting normal brain tissue.
我们研究了颈内注射组胺对移植大鼠C6胶质瘤血瘤屏障通透性以及血脑屏障通透性的影响。颈内输注生理盐水后，正常组织或肿瘤组织中均未出现明显的伊文思蓝（EB）外渗。相比之下，剂量为1和10微克/千克/分钟的组胺在肿瘤组织中产生了轻度至中度的EB外渗，而正常脑组织中未出现任何明显外渗。静脉注射H1和H2受体拮抗剂（各5毫克/千克）可减少组胺（10微克/千克/分钟）诱导的肿瘤组织中EB的外渗。这些结果表明，脑肿瘤血管对组胺的反应方式与正常脑毛细血管不同。因此，组胺可用于向脑肿瘤选择性给药而不影响正常脑组织。
