通过血流速度和脑灌注压的波形分析对头外伤患者进行脑自动调节功能测试。
Testing of cerebral autoregulation in head injury by waveform analysis of blood flow velocity and cerebral perfusion pressure.
作者信息
Czosnyka M, Guazzo E, Iyer V, Kirkpatrick P, Smielewski P, Whitehouse H, Pickard J D
机构信息
Neurosurgical Unit, University of Cambridge, Addenbrooke's Hospital, U.K.
出版信息
Acta Neurochir Suppl (Wien). 1994;60:468-71. doi: 10.1007/978-3-7091-9334-1_128.
Thirty five head injured patients were subjected to day-by-day monitoring of intracranial pressure (ICP), arterial blood pressure (ABP) and blood flow velocity (FV) in middle cerebral artery. Parameters describing cerebral autoregulation: flow velocity time average, systolic, diastolic values, pulsatility index (PI), estimate of cerebrovascular resistance (CVR = CPP/FV) etc. were analyzed as functions of CPP (ABP-ICP). The results show that for CPP below 55 mmHg the evidence of exhausted autoregulation can be observed in FV, CVR, PI. The method is helpful in assessment ot the optimal level of CPP in order to reduce the probability of ischaemic brain insults.
35例头部受伤患者接受了颅内压（ICP）、动脉血压（ABP）和大脑中动脉血流速度（FV）的每日监测。描述脑自动调节的参数：血流速度时间平均值、收缩压、舒张压值、搏动指数（PI）、脑血管阻力估计值（CVR = CPP/FV）等作为脑灌注压（CPP，即ABP - ICP）的函数进行分析。结果表明，对于低于55 mmHg的CPP，在FV、CVR、PI中可观察到自动调节功能衰竭的迹象。该方法有助于评估CPP的最佳水平，以降低缺血性脑损伤的可能性。
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