脑出血后的脑水肿：NMDA受体拮抗剂MK-801和D-CPPene的作用
Cerebral oedema following intracerebral haemorrhage: the effect of the NMDA receptor antagonists MK-801 and D-CPPene.
作者信息
Kane P J, Cook S, Chambers I R, Mendelow A D
机构信息
Department of Surgery (Neurosurgery), University of Newcastle upon Tyne, U.K.
出版信息
Acta Neurochir Suppl (Wien). 1994;60:561-3. doi: 10.1007/978-3-7091-9334-1_155.
The effects of pre-treatment with the NMDA receptor antagonists MK-801 and D-CPPene on the development of brain oedema were investigated in a rodent model of intracerebral haemorrhage. In acute experiments (4 hour survival) both drugs caused significant hypotension and had significant anaesthetic effects whilst conferring no protection against oedema formation. In chronic experiments (24 hour survival) MK-801 conferred no protection against brain oedema. With D-CPPene marginal protection against cortical oedema may have been conferred but this result should be interpreted with caution.
在啮齿动物脑出血模型中，研究了用N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801和D-CPPene预处理对脑水肿发展的影响。在急性实验（存活4小时）中，两种药物均引起显著低血压并具有显著麻醉作用，但对水肿形成没有保护作用。在慢性实验（存活24小时）中，MK-801对脑水肿没有保护作用。使用D-CPPene可能对皮质水肿有轻微保护作用，但该结果应谨慎解释。
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