Leinsinger G, Piepgras A, Einhäupl K, Schmiedek P, Kirsch C M
Department of Nuclear Medicine, University of Munich, Germany.
AJNR Am J Neuroradiol. 1994 Aug;15(7):1327-32.
To determine whether a standardized stimulation challenge with acetazolamide will be helpful for assessing the vasodilatory capacity in patients with obstructive cerebrovascular disease.
To establish normative data of the cerebrovascular reserve capacity, a group of 41 control patients was investigated. The regional cerebral blood flow was measured quantitatively before and after stimulation with acetazolamide using the xenon 133 inhalation method and dynamic single-photon emission CT.
A significant increase of regional cerebral blood flow was found after administration of 1 g of acetazolamide. By doubling the dose no significant further increase was measured. We found no correlation of either baseline or stimulated flow values with age. However, a linear dependence between the stimulated flow values and their respective baseline values was observed.
The standardized challenge with acetazolamide seems to be a reliable method to determine cerebrovascular reserve capacity quantitatively.
确定使用乙酰唑胺进行标准化刺激挑战是否有助于评估阻塞性脑血管疾病患者的血管舒张能力。
为建立脑血管储备能力的标准数据，对41名对照患者进行了研究。使用氙133吸入法和动态单光子发射计算机断层扫描，在乙酰唑胺刺激前后定量测量局部脑血流量。
给予1克乙酰唑胺后，局部脑血流量显著增加。剂量加倍后，未测得进一步的显著增加。我们发现基线或刺激后血流值与年龄均无相关性。然而，观察到刺激后血流值与其各自的基线值之间存在线性关系。
乙酰唑胺标准化挑战似乎是定量测定脑血管储备能力的可靠方法。
