Lyle W M, Hayhoe D A
J Am Optom Assoc. 1976 Jun;47(6):768-78.
Part I: Hard data concerning adverse drug reactions are notoriously difficult to obtain. Some of the problems arise because of: --patient variables including age, sex, genetic differences, and current illness. --multiple drug use, continuation of smoking, and use of alcohol. --variations in dose, duration of treatment, and route of administration. --some effects are not reported but many reported effects are not truly due to the drug indicated. Nevertheless, we need to be aware of potential adverse reactions. Our ability to recognize drug side effects will be improved if we have some idea which kinds of reaction may occur. Part I deals with the analgesics, sedatives, laxatives, antacids, antidiabetic agents, antihypertensives and cardiovascular drugs. Potential systemic and ocular adverse reactions are listed.
关于药物不良反应的确切数据极难获取。出现一些问题的原因如下：
患者变量，包括年龄、性别、基因差异和当前疾病。
多种药物联用、持续吸烟和饮酒。
剂量、治疗持续时间和给药途径的差异。
一些不良反应未被报告，但许多报告的不良反应并非真正由所提及的药物引起。尽管如此，我们仍需留意潜在的不良反应。如果我们对可能发生的不良反应类型有所了解，识别药物副作用的能力将会提高。第一部分涉及镇痛药、镇静剂、泻药、抗酸剂、抗糖尿病药、抗高血压药和心血管药物。列出了潜在的全身和眼部不良反应。
