硫酸脱氢表雄酮与美国男性医生心肌梗死风险：一项前瞻性研究。

Dehydroepiandrosterone sulfate and the risk of myocardial infarction in US male physicians: a prospective study.

作者信息

Newcomer L M, Manson J E, Barbieri R L, Hennekens C H, Stampfer M J

机构信息

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

出版信息

Am J Epidemiol. 1994 Nov 15;140(10):870-5. doi: 10.1093/oxfordjournals.aje.a117175.

DOI:10.1093/oxfordjournals.aje.a117175

PMID:7977274

Abstract

High levels of dehydroepiandrosterone sulfate (DHEAS) have been associated with decreased risks of cardiovascular disease. The authors analyzed DHEAS in plasma collected at baseline among 169 participants in the Physicians' Health Study who subsequently had a myocardial infarction and 169 matched controls. The mean prediagnostic plasma DHEAS levels between cases (p = 0.33) (mean, 3.54 mumol/liter; standard deviation, 2.30) and controls (mean, 3.61 mumol/liter; standard deviation, 2.16) did not differ significantly. The relative risk was 1.04 (95 percent confidence interval 0.42-2.60) comparing extreme quintiles after adjustment for several coronary risk factors. In conclusion, these findings do not support the hypothesis that elevated plasma DHEAS is associated with a decreased risk of coronary disease in men, but a small to moderate association cannot be excluded.

摘要

硫酸脱氢表雄酮（DHEAS）水平升高与心血管疾病风险降低相关。作者分析了在医师健康研究中169名随后发生心肌梗死的参与者及169名匹配对照者基线时采集的血浆中的DHEAS。病例组（p = 0.33）（均值，3.54μmol/升；标准差，2.30）和对照组（均值，3.61μmol/升；标准差，2.16）诊断前血浆DHEAS平均水平无显著差异。在对多个冠状动脉危险因素进行校正后，比较极端五分位数时相对风险为1.04（95%置信区间0.42 - 2.60）。总之，这些发现不支持血浆DHEAS升高与男性冠心病风险降低相关的假说，但不能排除存在小到中度关联。