先兆子痫与红细胞血影的钙腺苷三磷酸酶活性
Preeclampsia and calcium adenosine triphosphatase activity of red blood cell ghosts.
作者信息
Nardulli G, Proverbio F, Limongi F G, Marín R, Proverbio T
机构信息
Centro de Biofisica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas.
出版信息
Am J Obstet Gynecol. 1994 Nov;171(5):1361-5. doi: 10.1016/0002-9378(94)90161-9.
OBJECTIVE
The current work was undertaken to study the calcium adenosine triphosphatase activity of red blood cell membranes from pregnant women with preeclampsia.
STUDY DESIGN
Six normotensive and six preeclamptic pregnant women at 38 to 39 weeks of gestation were studied. The diagnosis of preeclampsia was made on the basis of blood pressure (> 140/90 mm Hg), proteinuria (> 0.5 gm of urinary protein per day), or edema. Hemoglobin-free red blood cell ghosts were prepared from the heparinized blood samples and were used to determine the calcium adenosine triphosphatase activity.
RESULTS
It was found that the calcium adenosine triphosphatase activity of preeclamptic women is diminished by about 50% compared with that of normotensive pregnant women.
CONCLUSION
A diminution of the calcium adenosine triphosphatase activity of erythrocytes in preeclampsia might be an indication that the in vivo activity of the calcium pump of these cells is diminished, which could, in turn, drive the cells to increase their cytoplasmic free calcium concentration.
目的
开展当前这项研究是为了探究子痫前期孕妇红细胞膜的钙腺苷三磷酸酶活性。
研究设计
对6名血压正常及6例子痫前期孕妇进行了研究，这些孕妇均处于妊娠38至39周。子痫前期的诊断依据为血压（>140/90 mmHg）、蛋白尿（每日尿蛋白>0.5克）或水肿。从肝素化血样中制备无血红蛋白的红细胞影，并用于测定钙腺苷三磷酸酶活性。
结果
发现子痫前期孕妇的钙腺苷三磷酸酶活性与血压正常的孕妇相比降低了约50%。
结论
子痫前期患者红细胞钙腺苷三磷酸酶活性降低可能表明这些细胞钙泵的体内活性降低，进而可能促使细胞增加其细胞质游离钙浓度。
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