美替洛尔相关性肉芽肿性虹膜炎。
Metipranolol-associated granulomatous iritis.
作者信息
Melles R B, Wong I G
机构信息
Department of Ophthalmology, Kaiser Permanente Medical Center, Redwood City, CA 94063.
出版信息
Am J Ophthalmol. 1994 Dec 15;118(6):712-5. doi: 10.1016/s0002-9394(14)72549-8.
PURPOSE
Topical metipranolol therapy for primary open-angle glaucoma has been associated with anterior granulomatous uveitis in the United Kingdom. We studied granulomatous uveitis reactions to topical metipranolol 0.3% therapy for primary open-angle glaucoma in two patients in the United States.
METHODS
Two patients, aged 71 and 81 years, were given topical metipranolol 0.3% therapy for primary open-angle glaucoma.
RESULTS
Both developed granulomatous uveitis. The iritis was associated with an increase in intraocular pressure in both patients and resolved on discontinuation of the drug. One patient was inadvertently rechallenged with metipranolol, and the iritis recurred.
CONCLUSIONS
Topical metipranolol 0.3% therapy may be associated with the development of granulomatous uveitis and a paradoxical increase in intraocular pressure.
目的
在英国，局部用美替洛尔治疗原发性开角型青光眼已与前部肉芽肿性葡萄膜炎相关。我们在美国对两名原发性开角型青光眼患者局部用0.3%美替洛尔治疗后的肉芽肿性葡萄膜炎反应进行了研究。
方法
两名患者，年龄分别为71岁和81岁，接受局部用0.3%美替洛尔治疗原发性开角型青光眼。
结果
两人均发生了肉芽肿性葡萄膜炎。虹膜炎在两名患者中均与眼压升高相关，停药后炎症消退。一名患者意外再次使用美替洛尔，虹膜炎复发。
结论
局部用0.3%美替洛尔治疗可能与肉芽肿性葡萄膜炎的发生及眼压反常升高有关。
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