Cudd T A, Wood C E
Department of Physiology, University of Florida, Gainesville 32610-0274.
Am J Physiol. 1994 Nov;267(5 Pt 2):R1235-40. doi: 10.1152/ajpregu.1994.267.5.R1235.
Small infusions of strong acid create large elevations in heart rate (HR), mean arterial pressure (MAP), adrenocorticotropic hormone (ACTH), cortisol, and thromboxane A2 (TxA2). We hypothesized that TxA2 is responsible for these hormonal and hemodynamic responses. Conscious sheep received HCl (1 N, 1 ml/min for 30 min) with or without receiving SQ-29548 [a TxA2/prostaglandin (PG) H2 receptor antagonist]. HCl increased TxB2 from 133 +/- 44 to 1,213 +/- 531 (SE) pg/ml while SQ-29548 + HCl increased TxB2 from 141 +/- 41 to 1,051 +/- 518 pg/ml. HCl decreased pH (7.464 +/- 0.015 to 7.413 +/- 0.011), arterial PCO2 (31.6 +/- 1.3 to 25.9 +/- 1.8 mmHg), and arterial PO2 (98.0 +/- 2.2 to 90.5 +/- 3.2 mmHg), and increased MAP (75 +/- 2 to 88 +/- 5 mmHg), HR (72 +/- 4 to 93 +/- 8 beats/min), hematocrit (25 +/- 1 to 29 +/- 2%), ACTH (154 +/- 41 to 549 +/- 217 pg/ml), and aldosterone (25 +/- 1 to 151 +/- 74 pg/ml) while these responses were prevented by SQ-29548. SQ-29548 reduced but did not prevent the cortisol response to HCl (9 +/- 2 to 23 +/- 10 ng/ml compared with 6 +/- 2 to 17 +/- 4 pg/ml after SQ-29548). K+ and aldosterone also increased after the end of SQ-29548 + HCl treatment (4.0 +/- 0.1 to 4.5 +/- 0.1 meq/l and 53 +/- 21 to 147 +/- 61 pg/ml, respectively). We conclude that TxA2 mediates the blood gas, MAP, HR, ACTH, and aldosterone responses to HCl infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
小剂量输注强酸会导致心率（HR）、平均动脉压（MAP）、促肾上腺皮质激素（ACTH）、皮质醇和血栓素A2（TxA2）大幅升高。我们推测TxA2是这些激素和血流动力学反应的原因。清醒的绵羊接受HCl（1N，1ml/min，持续30分钟），同时给予或不给予SQ - 29548[一种TxA2/前列腺素（PG）H2受体拮抗剂]。HCl使TxB2从133±44升高至1,213±531（SE）pg/ml，而SQ - 29548 + HCl使TxB2从141±41升高至1,051±518 pg/ml。HCl降低了pH值（从7.464±0.015降至7.413±0.011）、动脉血二氧化碳分压（从31.6±1.3降至25.9±1.8 mmHg）和动脉血氧分压（从98.0±2.2降至90.5±3.2 mmHg），并升高了MAP（从75±2升至88±5 mmHg）、HR（从72±4升至93±8次/分钟）、血细胞比容（从25±1升至29±2%）、ACTH（从154±41升至549±217 pg/ml）和醛固酮（从25±1升至151±74 pg/ml），而这些反应被SQ - 29548阻止。SQ - 29548降低但未阻止皮质醇对HCl的反应（分别为9±2至23±10 ng/ml和6±2至17±4 pg/ml）。在SQ - 29548 + HCl治疗结束后，钾离子和醛固酮也升高（分别从4.0±0.1升至4.5±0.1 meq/l和从53±21升至147±61 pg/ml）。我们得出结论，TxA2介导了对HCl输注的血气、MAP、HR、ACTH和醛固酮反应。（摘要截断于250字） ）
