Stern R G, Kahn R S, Davidson M, Nora R M, Davis K L
Schizophrenia Biological Research Center, Bronx VA Medical Center, N.Y.
Am J Psychiatry. 1994 Dec;151(12):1817-8. doi: 10.1176/ajp.151.12.1817.
Forty schizophrenic patients were treated with clozapine for 5 weeks. Patients were then classified as treatment responders or nonresponders according to a priori established criteria. After only 1 week of treatment, the responders showed a significant decrease on the Brief Psychiatric Rating Scale (BPRS) total score and the psychosis and tension subscale scores. Higher BPRS scores at baseline and larger improvements in BPRS scores after the first week predicted a more favorable outcome in this trial and yielded good classification accuracy.
40名精神分裂症患者接受了5周的氯氮平治疗。然后根据预先设定的标准将患者分为治疗反应者或无反应者。仅治疗1周后，反应者在简明精神病评定量表（BPRS）总分以及精神病和紧张分量表得分上就有显著下降。基线时较高的BPRS得分以及第一周后BPRS得分的较大改善预示着该试验会有更有利的结果，且分类准确率良好。
