不可触及乳腺病变的立体定向细针穿刺细胞学检查：258例连续穿刺病例分析

Stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: an analysis of 258 consecutive aspirates.

作者信息

Sarfati M R, Fox K A, Warneke J A, Fajardo L L, Hunter G C, Rappaport W D

机构信息

Department of Surgery, University of Arizona Health Sciences Center, Tucson.

出版信息

Am J Surg. 1994 Dec;168(6):529-31; discussion 531-2. doi: 10.1016/s0002-9610(05)80116-3.

DOI:10.1016/s0002-9610(05)80116-3

PMID:7977990

Abstract

BACKGROUND

The role of stereotactic fine-needle aspiration cytology (SFNAC) in the diagnosis of nonpalpable breast lesions is poorly defined.

PATIENTS AND METHODS

Data were prospectively collected from 225 consecutive patients with nonpalpable breast lesions who had aspiration cytology followed by immediate surgical excision.

RESULTS

Between 1988 and 1993, 258 such procedures were performed. The results of 84 (33%) were interpreted as benign, 84 (33%) as atypical, 28 (11%) as suspicious for malignancy, and 49 (19%) as malignant. In all, 88 (34%) surgical specimens were malignant. SFNAC had an 80% sensitivity, a 96% specificity, a 91% positive predictive value, and an 89% negative predictive value. There were 18 false-negative and 7 false-positive aspirates.

CONCLUSIONS

SFNAC for diagnosing nonpalpable breast lesions is moderately sensitive and highly specific, and has a high positive and negative predictive value. In conjunction with mammography and clinical assessment, the procedure is useful for determining which patients with nonpalpable breast lesions may require surgical biopsy.

摘要

背景

立体定向细针穿刺抽吸细胞学检查（SFNAC）在不可触及乳腺病变诊断中的作用尚不清楚。

患者与方法

前瞻性收集了225例连续的不可触及乳腺病变患者的数据，这些患者均接受了穿刺细胞学检查，随后立即进行手术切除。

结果

1988年至1993年间，共进行了258例此类操作。84例（33%）结果被判定为良性，84例（33%）为非典型，28例（11%）怀疑为恶性，49例（19%）为恶性。总计88例（34%）手术标本为恶性。SFNAC的敏感性为80%，特异性为96%，阳性预测值为91%，阴性预测值为89%。有18例假阴性和7例假阳性抽吸结果。