Paulino A F, Kenney R, Forman E N, Medeiros L J
Department of Pathology, Rhode Island Hospital 02903.
Am J Pediatr Hematol Oncol. 1994 Nov;16(4):348-51.
A 3-year-old girl with acute lymphoblastic leukemia developed typhlitis immediately after diagnosis and before the institution of chemotherapy.
Typhlitis is a necrotizing colitis that develops in immunodeficient patients with severe neutropenia. Most patients are leukemic children who are receiving or have received chemotherapy. Typhlitis in the absence of chemotherapy is rare. We report a fatal case of typhlitis in an untreated leukemic patient.
This case emphasizes the multifactorial pathogenesis of typhlitis, which may occur in the absence of chemotherapy.
Typhlitis should always be considered as a potential cause of acute sepsis and abdominal pain in a leukemic patient.
一名3岁急性淋巴细胞白血病女童在诊断后且在开始化疗之前立即发生了盲肠炎。
盲肠炎是一种在严重中性粒细胞减少的免疫缺陷患者中发生的坏死性结肠炎。大多数患者是正在接受或已经接受化疗的白血病儿童。未接受化疗时发生盲肠炎的情况罕见。我们报告一例未经治疗的白血病患者发生致命性盲肠炎的病例。
该病例强调了盲肠炎的多因素发病机制，其可能在未进行化疗的情况下发生。
在白血病患者中，盲肠炎应始终被视为急性脓毒症和腹痛的潜在原因。
