Saleh A A, Church M W, Johnston J M
Department of Ob/Gyn, Henry Ford Hospital, Detroit, MI 48202.
Alcohol Clin Exp Res. 1994 Aug;18(4):1009-12. doi: 10.1111/j.1530-0277.1994.tb00074.x.
Platelet-activating factor (PAF) induces platelet aggregation and hypotension. It has been implicated in embryonic implantation, fetal lung maturation, and parturition. Alcohol abuse is associated with platelet dysfunction, chronic hypertension, and alcohol-related birth defects. We hypothesized that alcohol may cause, in part, these effects by increasing the activity of PAF-acetylhydrolase (PAF-AH), thereby decreasing PAF concentration. Pregnant mice were given 3.5 g/kg of alcohol orally twice daily from gestation days 7-17. PAF-AH was measured on gestation days 5, 14, and 19 in pregnant females. Nonpregnant females were treated and sampled at parallel time intervals. Pair-fed and untreated control groups were also used. The maternal plasma PAF-AH decreased with gestational age in the untreated controls. Alcohol significantly increased PAF-AH levels in both the pregnant and nonpregnant animals. PAF deficiency might contribute to the tocolytic action of alcohol, as well as some alcohol-related pregnancy complications.
血小板活化因子（PAF）可诱导血小板聚集和低血压。它与胚胎着床、胎儿肺成熟及分娩有关。酗酒与血小板功能障碍、慢性高血压及酒精相关的出生缺陷有关。我们推测，酒精可能部分通过增加PAF-乙酰水解酶（PAF-AH）的活性，从而降低PAF浓度来引发这些效应。从妊娠第7天至第17天，每天给怀孕小鼠口服3.5 g/kg酒精两次。在妊娠第5、14和19天测定怀孕雌性小鼠的PAF-AH。非怀孕雌性小鼠在平行时间间隔接受处理并取样。还设立了配对喂食和未处理的对照组。在未处理的对照组中，母体血浆PAF-AH随孕周增加而降低。酒精显著增加了怀孕和未怀孕动物的PAF-AH水平。PAF缺乏可能有助于酒精的安胎作用以及一些与酒精相关的妊娠并发症。
