McKinney K A, Lewis S E, Thompson W
Royal Maternity Hospital, Belfast, UK.
Andrologia. 1994 Jul-Aug;26(4):235-40. doi: 10.1111/j.1439-0272.1994.tb00794.x.
The aim of the study was to compare the in vitro effect of pentoxifylline on human sperm motility when added prior to sperm selection and the persistence of the response after drug removal in normo- and asthenozoospermic individuals. The sperm samples were obtained from 22 men who were repeatedly asthenozoospermic or normozoospermic. Sperm movement was measured using computer-assisted semen analysis over 180 min. Percentage motility and progressive motility were increased in both normo- and asthenozoospermic samples (P < 0.05). Curvilinear velocity, amplitude of lateral head displacement and beat-cross frequency were increased in both groups (P < 0.05). Straight-line velocity was increased significantly in the normozoospermic group only. In both normo- and asthenozoospermic individuals pentoxifylline appeared to enhance sperm motility for at least 180 min after drug removal. This should prevent any potentially toxic effects of the drug on oocytes if it is used to enhance sperm motility during in vitro fertilization.
本研究的目的是比较己酮可可碱在精子筛选前添加时对正常和弱精子症个体精子活力的体外作用，以及药物去除后反应的持续性。精子样本取自22名反复出现弱精子症或正常精子症的男性。使用计算机辅助精液分析在180分钟内测量精子运动。正常和弱精子症样本中的活力百分比和前向运动能力均增加（P<0.05）。两组的曲线速度、头部横向位移幅度和鞭打交叉频率均增加（P<0.05）。仅正常精子症组的直线速度显著增加。在正常和弱精子症个体中，己酮可可碱在药物去除后似乎至少可增强精子活力180分钟。如果在体外受精期间用于增强精子活力，这应可防止该药物对卵母细胞产生任何潜在的毒性作用。
