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[甲状腺手术中的针吸细胞学检查(我们在104例手术病例中的经验)]

[Needle aspiration cytology in thyroid surgery (our experience in 104 operated cases)].

作者信息

Parmeggiani U, Bove F, Calabria M, De Falco M, Di Martino G G

机构信息

I Clinica Chirurgica, Seconda Università degli Studi di Napoli.

出版信息

Ann Ital Chir. 1994 Jan-Feb;65(1):59-67.

PMID:7978747
Abstract

In the least years Fine Needle Aspiration Biopsy (FNAB) is more and more becoming a routine exam in the thyroid diagnostics. Nevertheless, its exact role and diagnostic value is still an argument under discussion, in spite of well known usefulness and safety of the method. The aim of this study, based on our experience, is to verify, if and how much FNAB findings could have modified the diagnostic schedule, the surgical indications and the number of malignancies in a group of operated patients for thyroid nodular disease. In this experience a series of 104 patients have been studied in the Ia Clinica Chirurgica-Ia Facoltà, Università degli Studi di Napoli in the years 1988-90; the indication for a surgical treatment was due to a nodular thyroid disease. Aspiration cytology was performed in these patients before surgery and afterwards was determined the correlation between cytologic and hystological findings. The clinical and scan assessment also contributed to indicate the surgical management of the disease. On the basis of this study FNAB has to be considered as a quite reliable diagnostic tool in thyroid lesions; it results free of complications, with good sensitivity (75%), specificity (82.6%) and diagnostic accuracy (81.7%). A peculiar consequence of the use of cytology, is the increased number of adenoca (11.5%) preoperatively diagnosed, a percentage of which otherwise would have been a histopathological postoperative "surprise". However, the possibility of "false negative" and "false positive" lends further support to the concept that FNAB alone cannot determinate the choice between medical or surgical treatment of thyroid nodular lesions.

摘要

近年来,细针穿刺活检(FNAB)在甲状腺疾病诊断中越来越成为一项常规检查。然而,尽管该方法具有众所周知的实用性和安全性,但其确切作用和诊断价值仍是一个有待讨论的问题。基于我们的经验,本研究的目的是验证在一组因甲状腺结节疾病接受手术的患者中,FNAB的检查结果是否以及在多大程度上改变了诊断流程、手术指征和恶性肿瘤的数量。在这项研究中,1988 - 1990年间,那不勒斯大学医学院第一外科的104例患者接受了研究;手术治疗的指征是甲状腺结节疾病。在这些患者手术前进行了穿刺细胞学检查,之后确定了细胞学和组织学检查结果之间的相关性。临床和扫描评估也有助于确定疾病的手术治疗方案。基于这项研究,FNAB应被视为甲状腺病变中一种相当可靠的诊断工具;它没有并发症,具有良好的敏感性(75%)、特异性(82.6%)和诊断准确性(81.7%)。使用细胞学检查的一个特殊结果是术前诊断出的腺癌数量增加(11.5%),否则其中一部分在术后组织病理学检查时会“意外发现”。然而,“假阴性”和“假阳性”的可能性进一步支持了这样一种观点,即仅靠FNAB不能决定甲状腺结节病变是采用内科治疗还是手术治疗。

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