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健康土耳其人群血清脂蛋白(a)浓度分布情况

Distribution of serum lipoprotein (a) concentrations in a healthy Turkish population.

作者信息

Orem A, Değer O, Onder E, Karahan S C, Efe H, Uzunosmanoğlu D

机构信息

Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

出版信息

Ann Clin Biochem. 1994 Jul;31 ( Pt 4):343-6. doi: 10.1177/000456329403100406.

Abstract

Serum lipoprotein (a) [Lp (a)] concentrations are highly skewed in different populations. We measured serum Lp (a) by quantitative enzyme-linked immunosorbent assay (ELISA) in 248 healthy Turkish subjects (127 male, 121 female). The mean Lp (a) value was 0.21 g/L and values did not differ between the sexes. The Lp (a) frequency distribution showed less skewness than those of Asian and Western populations but it clearly deviated from a Gaussian distribution. Plasma Lp (a) concentration did not correlate significantly with age, total cholesterol, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, apolipoprotein A-1 and B or triglyceride concentration.

摘要

血清脂蛋白(a)[Lp(a)]浓度在不同人群中高度偏态分布。我们采用定量酶联免疫吸附测定法(ELISA)对248名健康土耳其受试者(127名男性,121名女性)的血清Lp(a)进行了检测。Lp(a)的平均浓度为0.21 g/L,且男女之间无差异。Lp(a)的频率分布比亚洲和西方人群的偏态性小,但明显偏离高斯分布。血浆Lp(a)浓度与年龄、总胆固醇、低密度脂蛋白(LDL)胆固醇、高密度脂蛋白(HDL)胆固醇、载脂蛋白A-1、载脂蛋白B或甘油三酯浓度均无显著相关性。

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