高胆固醇血症患者红细胞膜脂肪酸组成
Erythrocyte membrane fatty acid composition in hypercholesterolaemia.
作者信息
Taylor A J
机构信息
Department of Chemical Pathology, South Manchester Hospital, UK.
出版信息
Ann Clin Biochem. 1994 Jul;31 ( Pt 4):351-4. doi: 10.1177/000456329403100408.
The fatty acid composition of the erythrocyte membrane was determined in 22 hypercholesterolaemic patients managed by dietary restriction, and compared with that of 22 normocholesterolaemic controls, roughly matched for age and sex with the patient group. The patients exhibited higher relative proportions of palmitic (P < 0.01) and stearic (P < 0.005) acids and lower relative proportions of linoleic acid (P < 0.05) in the erythrocyte membrane, compared with controls, which could be due to presumed dietary differences between the groups. In the patients, the degree of hypercholesterolaemia was poorly correlated with erythrocyte linoleic acid. Measurement of erythrocyte linoleic acid might prove useful in the routine management of hypercholesterolaemia.
对22例通过饮食限制治疗的高胆固醇血症患者的红细胞膜脂肪酸组成进行了测定，并与22例胆固醇正常的对照者进行了比较，后者在年龄和性别上与患者组大致匹配。与对照组相比，患者红细胞膜中棕榈酸（P < 0.01）和硬脂酸（P < 0.005）的相对比例较高，而亚油酸的相对比例较低（P < 0.05），这可能是由于两组之间推测的饮食差异所致。在患者中，高胆固醇血症的程度与红细胞亚油酸的相关性较差。测定红细胞亚油酸可能在高胆固醇血症的常规管理中证明是有用的。
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