Sakaguchi Y, Stephens L C, Makino M, Kaneko T, Strebel F R, Danhauser L L, Jenkins G N, Bull J M
Department of Internal Medicine, University of Texas Medical School, Houston 77225.
Anticancer Res. 1994 Jul-Aug;14(4A):1489-92.
The induction of apoptosis in normal tissues was histopathologically examined in rats treated with 5-fluorouracil (5-FU). 5-FU was administered by either bolus intravenous injection or 72-hr prolonged intravenous infusion (PIF). Bolus injection and PIF of 5-FU induced different kinetic profiles of apoptosis in the thymus, spleen and ileum. The bolus injections of 5-FU induced a greater extent of apoptosis in these tissues, compared to PIF 5-FU. These data indicate that the kinetics and extent of apoptosis induced by 5-FU depends on the schedule of the 5-FU administration, and that 5-FU-induced toxicity may be related to 5-FU-induced apoptosis in normal tissues.
在接受5-氟尿嘧啶（5-FU）治疗的大鼠中，对正常组织中细胞凋亡的诱导进行了组织病理学检查。5-FU通过大剂量静脉注射或72小时持续静脉输注（PIF）给药。5-FU的大剂量注射和PIF在胸腺、脾脏和回肠中诱导了不同的细胞凋亡动力学特征。与PIF 5-FU相比，5-FU的大剂量注射在这些组织中诱导了更大程度的细胞凋亡。这些数据表明，5-FU诱导的细胞凋亡的动力学和程度取决于5-FU的给药方案，并且5-FU诱导的毒性可能与正常组织中5-FU诱导的细胞凋亡有关。
