Noguchi M
Dept. of Pathology, National Cancer Center Research Institute.
Gan To Kagaku Ryoho. 1994 Nov;21(15):2549-54.
Histological examination revealed that many peripheral type papillary adenocarcinomas appear to develop from atypical adenomatous hyperplasia (AAH), which can be called adenoma or in situ adenocarcinoma, and progress stepwise. Molecular-biologically, loss of heterozygosities of 3, 11 and 17 chromosomes, point mutation of ras oncogene and p53 anti-oncogene, amplification of myc oncogene, and overexpression of erbB2 oncogene are related to lung cancer development. Especially, ras and p53 gene abnormalities are closely associated with poor prognosis of lung adenocarcinoma. Future molecular-biological examinations should focus on AAH and/or early stage adenocarcinoma of the lung, in order to clarify the gene abnormality at the early stage of lung carcinogenesis.
组织学检查显示，许多外周型乳头状腺癌似乎由非典型腺瘤样增生（AAH）发展而来，AAH可称为腺瘤或原位腺癌，并呈逐步进展。从分子生物学角度来看，3号、11号和17号染色体的杂合性缺失、ras癌基因和p53抑癌基因的点突变、myc癌基因的扩增以及erbB2癌基因的过表达均与肺癌的发生发展相关。尤其是，ras和p53基因异常与肺腺癌的不良预后密切相关。未来的分子生物学检查应聚焦于肺的AAH和/或早期腺癌，以阐明肺癌发生早期的基因异常情况。
