Uchida K, Hayashi T, Shiga T, Hattori K, Nishijima Y, Kasaya S, Shimazui T, Akaza H, Koiso K, Nemoto R
Dept. of Urology, University of Tsukuba.
Gan To Kagaku Ryoho. 1994 Nov;21(15):2633-7.
Combination effect of UFT and leucovorin against the rat prostatic carcinoma (R-3327) was evaluated by the subrenal capsular assay (SRCA) using nude mice. Anticancer effect of UFT was augmented by co-administration of both low and high dose leucovorin. These results suggest a clinical usefulness of UFT administration with leucovorin for the patients with hormonally refractory advanced prostatic carcinoma.