Warner K J, Blackwell G G, Herrera G A, Listinsky C, Holman W L, Rustagi P K
Department of Pathology, University of Alabama at Birmingham 35294-3300.
Arch Pathol Lab Med. 1994 Nov;118(11):1148-50.
A 73-year-old man presented with dyspnea and atrial flutter associated with an amyloid tumor in the heart. IgM-kappa gammopathy, hypercalcemia, and extensive cardiac and mediastinal invasion suggested a malignant lymphoid or plasma cell process. Although amyloidoma is generally considered to be a benign tumor, the aggressive features of this case mandated chemotherapy because the critical location rendered the tumor inoperable. This case provides noteworthy evidence in support of a possible pathogenic relationship between amyloidoma and plasmacytoma by virtue of dual representative features: localized amyloid infiltrated with plasma cells and the associated gammopathy. Local and systemic malignant features lend additional support to this hypothesis.
一名73岁男性因呼吸困难和心房扑动就诊，心脏存在淀粉样瘤。IgM-κ型丙种球蛋白病、高钙血症以及广泛的心脏和纵隔侵犯提示为恶性淋巴或浆细胞病变。尽管淀粉样瘤通常被认为是良性肿瘤，但该病例的侵袭性特征使得必须进行化疗，因为肿瘤位置关键无法手术切除。该病例通过双重典型特征（局部淀粉样变伴浆细胞浸润及相关丙种球蛋白病）为支持淀粉样瘤与浆细胞瘤之间可能的致病关系提供了值得关注的证据。局部和全身的恶性特征进一步支持了这一假说。
