Nazaretian M K, Aĭbazian L K
Arkh Patol. 1993 Jan-Feb;55(1):52-7.
Experimental hypersiderosis was induced in rabbits by intravenous injection of iron-containing preparation Ferrum Leck. The resultant pronounced hemosiderosis was found in the liver, kidneys, heart, lungs and spleen. Dystrophic and necrotic processes arose in the liver, kidneys, heart. Accumulation of hemosiderin in the vascular walls led to their higher permeability, edema, wall thickness, proliferative changes, especially in the coronary vessels. Intravascular circulation impairment was evident from compression of microvessels by siderophages, red cells aggregation, formation of microthrombi.
通过静脉注射含铁制剂Ferrum Leck在兔子身上诱发实验性高铁血症。在肝脏、肾脏、心脏、肺和脾脏中发现了明显的含铁血黄素沉着症。肝脏、肾脏和心脏出现了营养不良和坏死过程。血管壁中含铁血黄素的积累导致其通透性增加、水肿、管壁增厚、增生性改变，尤其是在冠状血管中。血管内循环障碍表现为噬铁细胞对微血管的压迫、红细胞聚集和微血栓形成。
