Okura S I, Kaga K
Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan.
Auris Nasus Larynx. 1994;21(1):1-7. doi: 10.1016/s0385-8146(12)80002-2.
This report describes the histopathological findings of the middle ear in patients with leukemia and malignant lymphoma whose middle ear effusion (MEE) was observed from temporal bone specimens. There were 19 patients (35 ears) with leukemia and 8 patients (16 ears) with malignant lymphoma. MEE was observed in 8 of 35 ears with leukemia, and 5 of 16 ears with malignant lymphoma. In 8 ears with leukemia with MEE, pathological changes included effusion containing floating tumor cells in 4 and tumor infiltration around the Eustachian tube in 3. In 1 of 5 ears with malignant lymphoma with MEE, MEE was accompanied by tumor infiltration. Infection was present in 13 ears of patients with leukemia and malignant lymphoma. It is suggested that there are various causes, including infection, obstruction of the Eustachian tube with tumor infiltration and a tendency to bleed, of MEE in leukemia and malignant lymphoma.
本报告描述了从颞骨标本观察到中耳积液（MEE）的白血病和恶性淋巴瘤患者中耳的组织病理学发现。白血病患者19例（35耳），恶性淋巴瘤患者8例（16耳）。35例白血病患者中有8耳出现MEE，16例恶性淋巴瘤患者中有5耳出现MEE。在8例有MEE的白血病耳中，病理改变包括4耳积液中有漂浮肿瘤细胞，3耳咽鼓管周围有肿瘤浸润。在5例有MEE的恶性淋巴瘤耳中，有1耳MEE伴有肿瘤浸润。白血病和恶性淋巴瘤患者中有13耳存在感染。提示白血病和恶性淋巴瘤中MEE有多种病因，包括感染、肿瘤浸润导致的咽鼓管阻塞和出血倾向。
