所报告的心脏病家族史的准确性：“不知道”回答的影响。
Accuracy of reported family history of heart disease: the impact of 'don't know' responses.
作者信息
Silberberg J, Wlodarczyk J, Hensley M, Ray C, Alexander H, Basta M, Hughes J
机构信息
University of Newcastle, John Hunter Hospital, NSW, Australia.
出版信息
Aust N Z J Med. 1994 Aug;24(4):386-9. doi: 10.1111/j.1445-5994.1994.tb01466.x.
BACKGROUND
Usual 'Yes/No' definitions of a family history of heart disease do not allow for 'Don't know' responses. In some families, misclassification of family history may result if these are not considered.
AIMS
To study the accuracy of family history reporting and the impact of 'Don't know' responses.
METHODS
We compared reported family history of coronary heart disease (CHD) and cancer among 360 deceased relatives of 59 probands with 'gold standard' diagnoses recorded on official death certificates.
RESULTS
For first degree relatives, sensitivity of reporting was 81% for CHD, 86% for any heart disease and 60% for cancer, while for second degree relatives, sensitivity was 73%, 69% and 90%, respectively. When 'Don't know' responses were classified as 'No', sensitivity in first degree relatives was not affected, but in second degree relatives, it fell to 49%, 41% and 60%, respectively. Specificities were unchanged. These data show that in families where information beyond first degree relatives is considered, failing to account for 'Don't know' responses is likely to lead to misclassification of family history of CHD.
背景
常见的心脏病家族史“是/否”定义不允许“不知道”的回答。在一些家庭中，如果不考虑这些回答，可能会导致家族史的错误分类。
目的
研究家族史报告的准确性以及“不知道”回答的影响。
方法
我们将59名先证者的360名已故亲属报告的冠心病（CHD）和癌症家族史与官方死亡证明上记录的“金标准”诊断进行了比较。
结果
对于一级亲属，CHD报告的敏感性为81%，任何心脏病为86%，癌症为60%；对于二级亲属，敏感性分别为73%、69%和90%。当“不知道”的回答被归类为“否”时，一级亲属的敏感性不受影响，但二级亲属的敏感性分别降至49%、41%和60%。特异性不变。这些数据表明，在考虑一级亲属以外信息的家庭中，不考虑“不知道”的回答可能会导致CHD家族史的错误分类。
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