一种改进的丁酰胆碱酯酶表型分析方法。
An improved method for butyrylcholinesterase phenotyping.
作者信息
Picheth G, Fadel-Picheth C, Primo-Parmo S L, Chautard-Freire-Maia E A, Vieira M M
机构信息
Department of Biochemistry, Federal University of Paraná, Curitiba, Brazil.
出版信息
Biochem Genet. 1994 Apr;32(3-4):83-9. doi: 10.1007/BF00554417.
An improved method for the identification of butyrylcholinesterase phenotypes is proposed. It is based on modifications of a method that uses alpha-naphthyl acetate as substrate and DL-propranolol and Ro2-0683 as inhibitors. The proposed modifications make the method more rapid and increase the accuracy of the determinations of the phenotypes tested (BCHE U, BCHE UF, BCHE UA, BCHE AK, BCHE AF, and BCHE A). These modifications make the method even more adequate for population studies and clinical routine.
本文提出了一种改进的丁酰胆碱酯酶表型鉴定方法。该方法基于对一种以醋酸α-萘酯为底物、DL-普萘洛尔和Ro2-0683为抑制剂的方法的改进。所提出的改进使该方法更快，并提高了所测试表型（BCHE U、BCHE UF、BCHE UA、BCHE AK、BCHE AF和BCHE A）测定的准确性。这些改进使该方法更适用于群体研究和临床常规应用。
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