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古DNA:利用分子生物学探索过去

Ancient DNA: using molecular biology to explore the past.

作者信息

Brown T A, Brown K A

机构信息

Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, UK.

出版信息

Bioessays. 1994 Oct;16(10):719-26. doi: 10.1002/bies.950161006.

Abstract

Ancient DNA has been discovered in many types of preserved biological material, including bones, mummies, museum skins, insects in amber and plant fossils, and has become an important research tool in disciplines as diverse as archaeology, conservation biology and forensic science. In archaeology, ancient DNA can contribute both to the interpretation of individual sites and to the development of hypotheses about past populations. Site interpretation is aided by DNA-based sex typing of fragmentary human bones, and by the use of genetic techniques to assess the degree of kinship between the remains of different individuals. On a broader scale, population migrations can be traced by studying genetic markers in ancient DNA, as in recent studies of the colonisation of the Pacific islands, while ancient DNA in preserved plant remains can provide information on the development of agriculture.

摘要

在多种保存下来的生物材料中都发现了古代DNA,包括骨骼、木乃伊、博物馆收藏的兽皮、琥珀中的昆虫以及植物化石,并且古代DNA已成为考古学、保护生物学和法医学等众多学科中的一项重要研究工具。在考古学中,古代DNA有助于对单个遗址进行解读,也有助于提出关于过去人口的假设。基于DNA的残缺人类骨骼性别鉴定以及运用基因技术评估不同个体遗骸之间的亲属关系程度,有助于对遗址进行解读。在更广泛的层面上,通过研究古代DNA中的基因标记可以追踪人口迁移情况,如近期对太平洋岛屿殖民化的研究;而保存下来的植物遗骸中的古代DNA能够提供有关农业发展的信息。

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