Kilpatrick W S, Wosornu D, McGuinness J B, Glen A C
Department of Clinical Biochemistry, Victoria Infirmary, Glasgow, Scotland, UK.
Ann Clin Biochem. 1993 Sep;30 ( Pt 5):435-8. doi: 10.1177/000456329303000503.
We have measured changes in plasma concentration of creatine kinase MB (CK-MB) and myoglobin in 50 patients admitted to the Coronary Care Unit with chest pain of presumed cardiac origin. Eight serial blood samples were obtained in the 6 h period following admission and both CK-MB and myoglobin concentrations were measured. We compared the performance of single values of both tests. Myoglobin concentration, in the coronary care population studied, proved to be as specific as CK-MB concentration (92.6% in both cases) but with sensitivity of 100% being achieved 1.5 h post admission rather than 4 h post admission in the case of CK-MB. On this evidence, measurement of plasma myoglobin could prove useful in the rapid diagnosis of myocardial infarction with consequent effects on optimal Coronary Care utilisation and selection of patients for thrombolytic therapy.
我们对50名因疑似心脏原因胸痛而入住冠心病监护病房的患者，测量了其血浆肌酸激酶MB（CK-MB）和肌红蛋白浓度的变化。入院后6小时内采集了8份连续血样，并对CK-MB和肌红蛋白浓度进行了测量。我们比较了两种检测单一值的性能。在所研究的冠心病监护人群中，肌红蛋白浓度被证明与CK-MB浓度一样具有特异性（两者均为92.6%），但肌红蛋白在入院后1.5小时达到100%的敏感性，而CK-MB在入院后4小时才达到。基于这一证据，血浆肌红蛋白的测量可能对心肌梗死的快速诊断有用，从而对优化冠心病监护的利用以及溶栓治疗患者的选择产生影响。
